Ran drags spindles through the Mud
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Ran drags spindles through the Mud T he Ran GTPase orients the mitotic spindle by controlling the recruitment of a motor adaptor protein to the cell cortex, Wee et al. report. Spindle orientation can determine the fate of daughter cells by affecting the proteins they inherit or the position they occupy within a tissue. A key factor controlling spindle alignment is the protein Pins, which locali...
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متن کاملRan
How is Ran involved in nuclear transport? Cargo is transported through pores in the nuclear envelope, in association with carriers that bind to pore proteins called nucleoporins. A Ran–GTP gradient across the envelope is created by the asymmetric distribution of the GTPase activating protein known as RanGAP, which is in the cytosol, and of the guanine nucleotide exchange factor RanGEF in the nu...
متن کاملSmall GTPase Ran and Ran-binding proteins.
Abstract Like many other small GTPases, Ran functions in eukaryotic cells as a molecular switch that cycles between GTP- and GDP-bound forms. Through the proper modulation of the GTP/GDP cycle, Ran functions with a number of Ran-binding proteins to control a broad array of fundamental cellular functions, including nucleocytoplasmic transport, mitotic spindle assembly, and nuclear envelope and n...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2011
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1953iti1